王华 实验室执行主任 博士,教授,博导,主任医师
详细介绍
王华,二级教授,主任医师,博士生导师。国家级人才项目获得者。曾入选国家百千万人才工程、教育部新世纪人才和安徽省 。安徽医科大学第一附属医院肿瘤内科副主任,兼肿瘤免疫病区主任;安徽医科大学科技产业处处长。1999年毕业于安徽医科大学医学系临床医学专业,2005年获安徽医科大学临床药理研究所药理学博士学位。2007年至2014年在美国国立卫生研究院(NIH)酒精滥用与依赖研究所(NIAAA)肝病实验室开展科学研究。主要研究方向为肝损伤炎症与修复、肿瘤免疫,及相关药物研发。代表作发表在Hepatology,Journal of Hepatology,Gastroenterology,The American Journal of Pathology等。
研究方向:肝损伤炎症与修复,肿瘤免疫,及其相关药物研发。
联系方式:邮箱: wanghua@ahmu.edu.cn;wanghuaniaaa@outlook.com
近期主持的代表科研项目
1. 炎症免疫性疾病优秀科研创新团队,2022AH010047,安徽省教育厅优秀科研创新团队项目.
2. 肝损伤炎症与修复. 国家杰出青年科学基金. 82225008/H03,2023.1-2027.12.
3. p21缺失通过调节肿瘤免疫微环境促进肝癌发生的机制研究. 国家自然科学基金区域创新发展联合基金. U21A20375. 2022.1-2025.12.
4. Alcoholic liver disease: from hepatitis to failure. 中德合作交流项目(The Mobility Programme of the Sino-German Center for Research Promotion). M-0099. 2021.1-2023.12.
5. 髓系细胞在衰老加重酒精性肝病进程中的作用以及天然杀伤(NK)/NKT细胞的调节机制. 国家自然科学基金面上项目. 81770588/H0315. 2018.1-2021.12.
6. 肝再生和损伤修复. 国家优秀青年科学基金. 81522009/H0317. 2016.1-2018.12.
7. 髓系细胞STAT3在肝细胞癌微环境中可抑制抗肿瘤免疫反应. 国家自然科学基金面上项目. 81372577/ H1617. 2014.1-2017.12.
近期代表性论文:
1.Ren R, Yong He Y, Ding D, Cui A, Bao H, Ma J, Hou X, Li Y, Feng D, Li X, Liangpunsakul S, Gao B, Wang H*. Aging exaggerates acute-on-chronic alcohol-induced liver injury in mice and humans by inhibiting neutrophilic sirtuin 1-C/EBPα-miRNA-223 axis. Hepatology. 2022 Mar;75(3):646-660. doi: 10.1002/hep.32152.
2.Hou X#, Yin S#, Ren R, Liu S, Yong L, Liu Y, Li Y, Zheng MH, Kunos G, Gao B, Wang H* Myeloid cell-specific IL-6 signaling promotes miR-223-enriched exosome production to attenuate NAFLD-associated fibrosis. Hepatology. 2021 Jul;74(1):116-132. (Editorial comment: Gyongyi Szabo. Exosomes and MicroRNA-223 at the Intersection of Inflammation and Fibrosis in NAFLD. Hepatology; 2021 Jul;74(1):5-8. doi: 10.1002/hep.31805. Epub 2021 May 24.)
3.Wang H*, Mehal W, Nagy LE, Rotman Y. Immunological mechanisms and therapeutic targets of fatty liver diseases. Cell Mol Immunol. 2021. Jan;18(1):73-91. doi: 10.1038/s41423-020-00579-3. (Invited Review, Cover Figure)
4.Xu L#,Yang Y#,Wen X, Jeong J, Emontzpohl C, Atkins C, Sun Z, Poulsen K, Hall D, Bynon J, Gao B, Lee W, Rule J, Jacobsen E, Wang H*, Ju C*. Hepatic recruitment of eosinophils and their protective function during acute liver injury. J of Hepatol. 2022, Aug;77(2):344-352. doi: 10.1016/j.jhep.2022.02.024.
5.Xu L#, Yang Y#, Jiang J, Wen Y, Jeong JM, Emontzpohl C, Atkins CL, Kim K, Jacobsen EA, Wang H*, Ju C*. Eosinophils protect against acetaminophen-induced liver injury through cyclooxygenase-mediated IL-4/IL-13 production. Hepatology. 2022 Jun 17. doi: 10.1002/hep.32609.
6.Xiao J#, Wang F#, Wong NK, He J, Zhang R, Sun R, Xu Y, Liu Y, Li W, Koike K, He W, You H, Miao Y, Liu X, Meng M, Wang H*, Li C*. Global Liver Disease Burdens and Research Trends: Analysis from a China Perspective. J Hepatol. 2019 Jul;71(1):212-221. (Public Health)
7.Liu JT#, Fan LL#, Yu HQ#, Zhang J#, He Y, Feng DC, Wang F, Li XQ, Liu QQ, Li YH, Guo ZL, Gao B, Wei W, Wang H*, Sun GP*. Endoplasmic reticulum stress promotes liver cancer cells to release exosomal miR-23a-3p and up-regulate PD-L1 expression in macrophages. Hepatology. 2019 Jul;70(1):241-258.
8.Ramirez T#, Li YM#, Yin S#, Xu MJ, Feng D, Zhou Z, Zang M, Mukhopadhyay P, Varga ZV, Pacher P, Gao B*, Wang H*. Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating Sirtuin 1 expression. J Hepatol. 2017; 66(3):601-609. (Cover Story)